منابع مشابه
Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site.
UNLABELLED Nanobodies, or VHHs, that recognize poliovirus type 1 have previously been selected and characterized as candidates for antiviral agents or reagents for standardization of vaccine quality control. In this study, we present high-resolution cryo-electron microscopy reconstructions of poliovirus with five neutralizing VHHs. All VHHs bind the capsid in the canyon at sites that extensivel...
متن کاملCross-neutralizing human anti-poliovirus antibodies bind the recognition site for cellular receptor.
Most structural information about poliovirus interaction with neutralizing antibodies was obtained in the 1980s in studies of mouse monoclonal antibodies. Recently we have isolated a number of human/chimpanzee anti-poliovirus antibodies and demonstrated that one of them, MAb A12, could neutralize polioviruses of both serotypes 1 and 2. This communication presents data on isolation of an additio...
متن کاملProduction and Characterization of a Monoclonal Antibody Neutralizing Poliovirus Type 2
Monoclonal Antibodies (mAbs) are used for biomedical research, diagnosis, treatment, production, and the quality control of biological products. mAbs are also very helpful in poliovirus research studies because it is still one of the major public health problems in developing countries. The main objective of this study was the production of mAbs against Poliovirus Type 2 (PV2) to be prepared an...
متن کاملThe Formation and Properties of Poliovirus-neutralizing Antibody
Rapid formation of poliovirus-neutralizing antibody was observed in the rabbit. 19S type antibody was detectable 8 to 12 hours following a single intravenous virus injection and the induction period was of the order of 4 to 5 hours or less. The production of 7S antibody had a longer lag phase (1(1/2) to 2 days) and it was formed at slower rate. The observed rate of early 19S and 7S antibody for...
متن کاملPoliovirus neutralization test with poliovirus pseudovirus to measure neutralizing antibody in humans.
We complement Arita et al. (1) for their development of a safe, simple, and rapid test, employing poliovirus pseudovirus (generating luciferase signals) instead of the wild poliovirus, to measure the poliovirus neutralizing antibody titer in human serum. Apart from the end game of the global poliomyelitis eradication program, poliovirus pseudovirus technology (1) would be advantageous in the su...
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ژورنال
عنوان ژورنال: Nature
سال: 1983
ISSN: 0028-0836,1476-4687
DOI: 10.1038/304395a0